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a sample from a healthy subject not suffering from the biomarker-related disease) and preferably the average biomarker expression level in several control samples is at least 10% and more preferably 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, 10.5, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20-fold or more

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Starting at a lower dose and gradually increasing under medical supervision is advised

doi: 10.1016/j.jcmg.2008.08.007 39 BotneyMDKaiserLRCooperJDMechamRPParghiDRobyJet al