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Obesity and insulin resistance are associated with endothelial dysfunction, sympathetic nervous system hyperactivity, and hyperleptinaemia, all of which can lead to hypertension

Providers should transition to emerging weight loss peptides when a patient experiences intractable side effects (like severe nausea or gastroparesis), when they hit a hard weight loss plateau despite dietary compliance, or when the primary clinical obstacle is documented cellular metabolic resistance rather than hyperphagia (overeating)

Mattioli, D

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Bulgart et al., 2020