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High methylation of upstream genes of ER suppresses ER expression, thereby promoting tamoxifen resistance, such as p21, WT1, and miR-27b

Human LST1 isoform 4(NP _995311.2) may be encoded by transcript variant 4(NM _205839.2) that includes additional exons in the 5 'UTR and uses alternating in-frame splice sites in the 3' coding region compared to variant 1

In an NPC mouse xenograft model, the delivery of prodrugs through engineered Lp leads to a 67% inhibition in tumor growth, significantly enhancing the efficacy of SN-38 by 54%

It is closer to the South American Continent than any other African State, being about 1,600 km from Brazil (Wiles 2005)

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