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These studies showed that a high housing temperature could not only affect the growth of animals, but also affected the immune functions and could aggravate inflammation ( Our data are in agreement with previous studies which suggested that the frequencies of CD4 + and CD8 + T cells could be increased by chronic heat stress ( In addition to helper T cells, macrophages and neutrophils play an important role in autoimmune diseases such as EAU ( Previous studies have suggested that the intermediates -ketoglutaric acid, fumaric acid and succinic acid of the aerobic respiration-related TCA cycle were increased in plasma from animals kept at a high ambient temperature ( Our study has several limitations

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10.1038/jcbfm.2014.119 J

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The canonical axis is governed by redox-tunable cysteines in IKK (Cys179) and in the DNA-binding cores of p65 (Cys38) and p50 (Cys62)