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10.1016/j.saa.2020.118804 2 AsifA.HeiskanenA.EmnusJ.KellerS

CCAT1 lncRNA Promotes Inflammatory Bowel Disease Malignancy by Destroying Intestinal Barrier via Downregulating miR-185-3p

Increased metabolic rate and ATP consumption trigger mitochondrial dysfunction, consequently leading to reactive oxygen species (ROS) over-production (Tamaki et al., 2014), which is the basis of increased oxidative stress, even in the early stage of CKD

One study identifies miR-125b-5p as a tumor-suppressive microRNA that is significantly downregulated in CRC tissues and cell lines ( In vivo models further validated these findings: suppression of miR-125b-5p promoted CRC lung metastases, whereas RSV treatment effectively hindered this process

Saffron, a spice obtained from the flowers of Crocus sativus , has been used in traditional medicine for thousands of years, with recent studies demonstrating its anti-inflammatory and immune-modulating effects