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One of the most heavily cited landmark studies, conducted by Vermeulen et al

84 Schwelberger, H

Taking it as a supplement makes it much more powerful than simply eating food that it might be found in

Mitochondrial dynamics in neuronal injury, development and plasticity

For instance, TMAO triggers NLRP3 inflammasome formation and activates NF-B signaling, Caspase-1, the PERK/Akt/mTOR pathway, and IL-1, leading to increased renal fibrosis (Zhang et al., 2020