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The third class of biologics is the IL-12 and IL-23 agonists

The biomarker methylmalonic acid in urine is sensitive, detecting early functional vitamin B12 deficiency before the onset of macrocytic anemia, as noted for MMA in serum

Hydroxocobalamin Another man-made injectable form of vitamin B12 is hydroxocobalamin, which lasts longer in the bloodstream and requires fewer injections than cyanocobalamin

Synthetic hormones, specifically progestins, by an oral route led to the creation of metabolites in the liver which caused an increase in the incidence of breast and uterine cancers

doi: 10.4161/pri.4.2.11960 51 DisantoG.AdiutoriR.DobsonR.MartinelliV.Dalla CostaG.RuniaT.et al