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7-Hydroxycoumarin (7-HC) can alleviate renal tubule expansion, epithelial cell detachment, and necrosis in the colistin-induced kidney injury mice model and the mice RTECs treated with colistin, and this protective effect is achieved by reducing the level of HDAC1, activating the Nrf2 signaling pathway to upregulate the protein expressions of Nrf2, HO-1, and H3K27AC, thereby enhancing the kidneys antioxidant capacity

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