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In the normal state when gluatione stores are adequate gluathione exerts a negative feedback inhibition on the enzyme -glutamyl cysteine synthase which regulates the cycle

2019;10 doi: 10.3389/fimmu.2019.00277

For the protein solutions the excitation wavelength was fixed at 295 nm (maximum absorbance = 0.10 OD) and emission spectra were recorded between 310 and 410 nm with an emission slit width of 2.5 nm

Short N, Jabbour EJ, Ravandi F, Huang X, Jain N, Sasaki K, Pemmaraju N, Daver NG, Khoury JD, Jorgensen JL, Alvarado Y, Konopleva MY, Garcia-Manero G, Kadia TM, Yilmaz M, Borthakur G , Burger JA, Kornblau SM, Wierda WG, DiNardo CD, Ferrajoli A, Nasnas P, Jacob J, Garris RE, OBrien SM, Kantarjian H

As an NADPH-selective enzyme, FSP1 suppresses ferroptosis by oxidizing NADPH