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In addition, immunosuppressive cells target effector cells through the expression of immune checkpoint proteins, e.g., the PD-1/PD-L1 and CTLA-4 proteins, which suppress the activation of T cells and prevent antigen-presentation

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It is worth noting that at the 10-week time point in the remyelination process, the four diffusion tensor metrics indicated the continual destruction of the sCC structure and the exacerbation of demyelination, while the T 2 -nor value was instead reduced

Front Immunol 2022;12:793260.ArticlePubMedPMC 45

Antibodies used: Alexa Fluor 647 anti-mouse CD3 antibody (BioLegend, 1:600)