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D., Grzekowiak, L

Because collagen is found throughout the body, EDS can impact multiple systems, including: Joints and ligaments Muscles and connective tissues Blood vessels Digestive system Autonomic nervous system Many individuals with EDS also experience related conditions such as: POTS (Postural Orthostatic Tachycardia Syndrome) Dysautonomia Chronic fatigue Migraines Anxiety disorders ADHD-like symptoms Sensory sensitivities Sleep difficulties Although EDS is considered a connective tissue disorder, many symptoms are closely tied to how the nervous system functions

Under oxidative stress or xenobiotic stress and increased ROS levels, Nrf2 dissociates from Keap1 and translocates to the nucleus where it binds antioxidant response elements (ARE) and activates the transcription of associated genes 50

Available at: Manning NJ, Allen EK, Kirk RJ, Sharrard MJ, Smith EJ

They can help prevent damage from forming within artery walls and protect against dangerous cholesterol plaque buildup, in addition to fighting weight gain and obesity