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On the contrary, numerous investigations revealed that VEGFR1 is critical for tumor growth and metastasis 35,36,37,38 , supporting the notion that the simultaneous blockade of VEGFR1 and VEGFR2 is required for effective suppression of tumor angiogenesis, growth and metastasis 20

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While early and smaller trials showed promising fat-loss effects, the largest Phase IIb trial did not achieve statistical significance in humans for its primary endpoint of weight reduction, which led to the program being discontinued

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