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A recent data science evidence-based approach to determine the top ten ingredients in oral skin supplements (from 71,000 dietary ingredients of which 1781 were found to have at least one skin-related publication assessed in human clinical trials) found that collagen had the most published human skin health-related data, followed by specific antioxidants (especially from natural sources or products) [25]

Antioxidants have been demonstrated to dramatically reduce or prevent free radical damage to the skin

In multivariable analysis, authors adjust for corticosteroids, but do not adjust for HCQ use which was a

Causal relationship between gut microbiota and autoimmune diseases: a two-sample mendelian randomization study

de Groot et al., Reference de Groot, Semin and Smeets2014), indicating a degree of independence between visual and odour cues