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[117] In cultures of dopaminergic neurons, the cytokines IL-1 and IL-6 protected against MPP+ toxicity

This activation induced the expression of pro-fibrotic genes such as -smooth muscle actin and fibronectin, leading to TM fibrosis and obstructed aqueous humor outflow (Wan et al., 2021

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This matters a lot because a lot of actives (like vitamin C) needs a specific pH to work well and feel comfortable on skin