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Such events require tight regulation, and changes in FASN activity might cause interferences due to the following reasons: (1) FASN activity accounts for the highest cell consumption of NADPH 1 , a key regulator of the REDOX balance, which is altered but highly regulated in cancer cells 32

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Lipid elution was achived using 10 mM ammonium formate and 0.1% formic acid in 60% acetonitrile/water mixture (A) and in 90% isopropanol/acetonitrile mixture (B) as mobile phase

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