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aim for at least 150 minutes of moderate exercise weekly as recommended by NHS guidelines Establish a regular toilet routine , allowing sufficient time after meals when the gastrocolic reflex is strongest Avoid delaying the urge to open your bowels, as this can worsen constipation over time Review your supplement formulation with your pharmacist

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43,44 Deficiency of B vitamins may contribute to disease pathology because of their essential role in production of serotonin, catecholamines, and other monoamines

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