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Although the positive and negative liposomes exhibited strong fluorescence intensity in the olfactory bulb and no significant intensity localization, the non-PEGylated neutral liposomes displayed greater migration into the brain via the olfactory and trigeminal nerve pathways

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Traditional mast cell activation (antigen binding) causes both: an immediate reaction and a delayed reaction Immediate reaction: The immediate reaction happens quickly, within minutes, causing the mast cell to degranulate and release its chemical-filled granules into the surrounding area

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