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the endothelial cells have a negative surface charge that repulses negatively charged compounds

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(1) modulating antigen presentation to lymphocytes, thereby influencing cytokine production and type of response (cellular or humoral) that develops, (2) enhancing proliferation of lymphocytes, thereby increasing magnitude of response, (3) enhancing killing activity of cytotoxic T cells and NK cells, and (4) regulating apoptosis, thereby maintaining control of the immune response

First, although the internal consistency of the biological signals observed is strong, the absence of a comparator groupsuch as patients receiving alternative iron chelators or no chelationprecludes conclusions about specificity