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SAT1 can sensitize oxidative stress-mediated ferroptosis through arachidonate 15-lipoxgenase (ALOX15) induction 69 , but little is known regarding the connection between SAT1 and necroptosis

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Excess copper accumulation can stimulate microglial activation, prompting the release of more pro-inflammatory cytokines such as TNF- and IL-1, which further exacerbate local neuroinflammatory responses (235)

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The authors also thank Dr