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They further suggested that once a phytochemical is shown to exert an effect in vivo , their mechanisms can be tested in vitro to avoid disappointments when testing in vitro concepts in vivo

Despite these advances, several technical challenges and limitations remain

doi: 10.1038/s41598-021-93697-5 148 RaoM

The administration of N-acetylcysteine (a medication to prevent or lessen kidney damage) before IV contrast for radiologic imaging may help reduce the risk of kidney damage

Importantly, the controlled nature of the GF-MKD likely reduced dietary coumarin exposure, and the observed post-intervention decline may therefore reflect both dietary restriction and altered metabolic or microbial handling of coumarin in children with ASD