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Disruption of Escherichia coli Nissle 1917 K5 capsule biosynthesis, through loss of distinct kfi genes, modulates interaction with intestinal epithelial cells and impact on cell health

Gelotte CK, Zimmerman BA (2015): Pharmacokinetics, Safety, and Cardiovascular Tolerability of Phenylephrine HCl 10, 20, and 30 mg After a Single Oral Administration in Healthy Volunteers

This metabolic adaptation can be relevant in triple-negative breast cancers (those lacking ERs, PRs and HER2, which constitute approximately a quarter of breast tumours) that express xCT, which exhibit increased levels of ROS induced by decreased glutamate levels upon glutamine scarcity