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Levels of KL-6 (a marker for AEC injury), ColIV1, and ColIV3 (markers for BM destruction) were significantly elevated in the serum of animals in the induced group, signifying that BLM caused AEC damage that resulted in the release of KL-6 23 and recruitment of inflammatory cells (e.g., monocytes) leading to the release of MMPs which results in further degradation of the surrounding BM and the release of collagen type IV fragments into the blood circulation 58,64

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While oxidative stress is elevated in obesity and metabolic syndrome, supplementing antioxidants doesn't reverse the hormonal drivers of weight gain (leptin resistance, elevated ghrelin, insulin resistance)

R01AR064350 (to G.C.T) and no