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Probably the most important example for such an alternative concept is the mitochondrial cascade hypothesis put forward already years ago by Swerdlow and coworkers, assuming mitochondrial dysfunction with enhanced oxidative stress and elevated free radical (ROS) production as the major pathomechanism of AD which slowly develops by aging and finally leads to the clinical disease

Notably, intravenous administration of macrophages alone, at an equivalent quantity, achieved a comparable effect to that observed in the drug-only monotherapy groups (Supplementary Figure S9A-C)

Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats

2 Other Testing Blood tests may be ordered to help identify possible causes of dizziness and vertigo such as anemia, infection, and thyroid or autoimmune disease, and hearing tests may be used to detect problems related to the inner ear, or the cranial nerve or brain region involved in hearing