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doi: 10.3389/fphar.2025.1719384 Received 06 October 2025 Revised 01 November 2025 Accepted 03 November 2025 Published 26 November 2025 Volume 16 - 2025 Edited by Gvozden Rosic, University of Kragujevac, Serbia Reviewed by Kandasamy Neelamegam, Tulane University, United States Ciniraj Raveendran, Government Medical College, India Updates Copyright 2025 Yan, Song, Zhang, Hu, Wang, Guo, Wang, Ma and Liu

Yue Zhang, orcid.org/0009-0008-0210-837X

Prognostic and aetiological relevance of 8-hydroxyguanosine in human breast carcinogenesis

This dual approach allows for the evaluation of compound warhead activity while assessing the in vivo clearance ability, facilitating the screening of compounds with appropriate reactivity, selectivity, and safety

Oxidative stress is related to overwhelming ROS production, with mitochondria being the main source of ROS through the electron transport chain [14, 15]