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Description

Specifically, hepatoma cells with low expression of GOT2 showed a high dependence on Gln metabolism by increasing Gln metabolism, nucleotide synthesis, and glutathione synthesis to support cellular antioxidants (Fig

L., & Kaplan, P

Growth of the mdh mutant on L-malate was still possible due to the presence of an L-malate dehydrogenase as part of the TCA cycle

145 Existing preclinical and clinical experiment data show that Gln inhibitor CB-839 joint capecitabine can effectively treat type PI3KCA mutations in colorectal cancer (NCT02861300)