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Network analysis shows that Nrf2 target genes such as Gclc and Nqo1 are tightly interconnected via highcorrelation edges with macrophageIFN effector genes such as Adgre1 and Rsad2, implying that oxidative metabolism and IFN amplification are not parallel events but are driven by a common transcriptional regulatory framework ( Nrf2 can initiate antioxidant genes via ROS sensing, whereas IRF7 acts as the core amplifier in the IFN positive feedback, and reports that they share binding sites in open chromatin regions provide a possible transcriptional basis for the dual regulation of the module ( 4.1 Limitations This study recalculated the lung transcriptome of the B240influenza model using singlecolor Agilent microarrays

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