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Together, these primary data delineate a pathogenic axis spanning focal iron accumulation, peripheralcentral iron imbalance, and ferroptosis susceptibility in early AD. Further evidence shows that ferritin levels in cerebrospinal fluid (CSF) can predict the rate of cognitive decline and are significantly associated with both A-positivity on PET imaging and elevated t-Tau concentrations

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However, no studies analyzed antioxidant levels in atomic bomb survivors

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2.7 Enzyme-linked immunosorbent assay (ELISA) After euthanasia, mouse heart blood was collected, incubated at room temperature (23C 2C) for 2 h, and centrifuged at 13,500 g for 10 min at 4C