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Anyone taking high-dose supplements should make sure to have their vitamin B12 levels tested periodically

How To Test For A Vitamin B12 Deficiency The simplest way to assess your vitamin B12 levels is to ask your doctor for a complete blood count, also known as a CBC, and get your vitamin B12 levels tested (read on to find out why this may not be the most accurate way)

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Several factors can impair B12 absorption: Reduced stomach acid production (achlorhydria or hypochlorhydria), common in older adults and those taking proton pump inhibitors or H2-receptor antagonists long-term, impairs the release of B12 from food proteins Pernicious anaemia , an autoimmune condition destroying parietal cells and reducing intrinsic factor production, completely blocks the primary absorption pathway Gastrointestinal disorders including Crohn's disease, coeliac disease, or surgical removal of stomach or ileum sections directly damage absorption sites Metformin , commonly prescribed for type 2 diabetes, may reduce B12 absorption through unclear mechanisms