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One reason for the contradictory results of RGD-GHK binding in vitro and in vivo could be that high-molecular-weight peptide hindered the penetration and retention of sOtx2-GHK in the skin

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10.1038/s12276-023-01047-4 58 JensterleM.KravosN

Additional analysis also revealed that AdoCblcould prevent neurotoxicity and dopamine deficits in fly and mouse models carrying different LRRK2 mutations associated with Parkinsons