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Consistent with Rana [47] and Demircan [46], we observed significant elevations in GRP78, PERK, ATF4, XBP1, and CHOP, indicative of UPR activation and pro-apoptotic ER stress signaling [44, 45, 46, 47]

They said two things: One, the label wasnt clear, and, two, they always thought it was a perfectly safe drug. McNeil said that it had asked Lee and Erush for patient information in order to examine their conclusions

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Findings suggest that binding at hypothalamic receptors may promote neuropeptides such as NPY and AgRP, both linked to hunger pathways