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10.1073/pnas.1423009112 7 DeNicolaG

doi: 10.1007/s00401-021-02384-2 153

Among these, scientific validation has confirmed that only 450 of these plants possess properties capable of lowering blood glucose levels, with 109 of them having well-documented mechanisms of action (203)

Historically used for a variety of conditions involving smooth muscle spasms in various systems: CNS migraine headache prophylaxis Respiratory seasonal allergies rhinitis asthma Urinary tract spasms, especially in the presence of stones and gravel renal colic urolithiasis nephrolithiasis Antispasmodic Antiinflammatory Antiallergic Gastroprotective Bitter Sesquiterpenes Pyrrolizidine Alkaloids Flavonoids Test444 Pregnancy and lactation: Avoid use since safety has not been established