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Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: implications for mitochondria-specific therapies and probes

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Siltuximab: This chimeric, anti-IL-6 monoclonal antibody was developed by Johnson & Johnson

These data suggest that aging increased oxidative stress and therefore lowered the GSH/GSSG ratio as compared to muscles in young adult animals and that aging reduced that ability to tolerate increased oxidative stress in chronically loaded skeletal muscles