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Following endocytosis, the HoloTC complex is degraded in lysosomes and free B12 is released into the cytoplasm, via CblF (Rutsch et al., 2009) and CblJ ( This free cytoplasmic B12 undergoes a series of intracellular transport and modifications to enable two core enzymatic reactions: 1) adenosyl-B12 acts as a co-factor for the enzyme methylmalonyl-coA mutase that catalyzes the conversion of methylmalonyl-coA to succinyl-coA, thereby enabling restoration of tricarboxylic acid (TCA) cycle intermediates and 2) methyl-B12 enables methionine synthase in the re-methylation of homocysteine to methionine using methyl-tetrahydrofolate (MTHF) as a methyl donor, thereby enabling the vital biochemical pathways of the folate cycle and methionine cycle, facilitating the downstream synthesis of important compounds like DNA and RNA (Figure 2)

Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice (in Eng)

While other peptides may address specific aspects of fat loss, 5-Amino-1MQs targeted action on NNMT offers a novel and promising approach to improving metabolic health

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B-complex vitamins, including B5 and B6, play a role in creating neurotransmitters such as serotonin and dopamine, which are important for controlling mood and stress levels