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They are more common in individuals with fair skin, but can occur in people of all skin types

Retinoids: Tretinoin, one of the types of retinoids, improves the rate of skin cell shedding and can gradually reduce the darkness of the spots

Figure 4 These three cases show how exposure to different types of toxic metals (elemental mercury, organic mercury, and silver) can result in some overlap in their distribution in the brain (e.g., all present in the locus ceruleus), but that different regions and cells of the brain can be affected (e.g., either grey or white matter oligodendrocytes)

Induction of neurite outgrowth in PC12 cells by alpha-phenyl-N-tert-butylnitron through activation of protein kinase C and the Ras-extracellular signal-regulated kinase pathway

These findings emphasize that oxidative phosphorylation is not only disrupted by hyperglycemia but also acts as a sustained source of ROS that drives retinal cell injury