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It is known that autophagy is defective in dopaminergic neurons in the SN, as observed in post-mortem brains of patients and certain models of PD like 6-OHDA and rotenone-induced models, which show suppression of mTOR, a key enhancer of autophagy (Grassi et al., 2018)

nutritional (food)is important because under the FD&C Act, vitamins and other supplements are treated as a subset of food products rather than drug products

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Nakayasu et al., 2017)

Disease-toxicant screen reveals a neuroprotective interaction between Huntingtons disease and manganese exposure