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Some of the key signs of low B12 to look out for include: Muscle weakness Numbness and tingling in the hands and feet Difficulty walking Nausea Weight loss Irritability Fatigue Rapid heart rate (7) One of the other tell-tale symptoms of a B12 deficiency is constant fatigue or being tired all the time, which can also manifest as sleep disturbances, including insomnia in some people, often requiring sleep medications

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Muscle burns significantly more calories at rest than fat tissue, so protecting muscle mass partially offsets the metabolic slowdown that typically accompanies caloric restriction

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High-risk groups include individuals with functional or anatomic asplenia, HIV infection, leukemia, lymphoma, Hodgkins disease, multiple myeloma, generalized malignancy, chronic kidney failure, nephrotic syndrome, or other immunosuppressive conditions