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In vitro studies by Matalka et al

1 H NMR (400 MHz, DMSO- d 6 ) 12.44 (s, 1H), 11.14 (s, 1H), 9.66 (s, 1H), 7.877.75 (m, 2H), 7.707.58 (m, 1H), 7.41 (d, J = 4.6 Hz, 1H), 6.72 (d, J = 1.8 Hz, 1H), 5.13 (dd, J = 12.7, 5.4 Hz, 1H), 4.07 (s, 2H), 3.55 (d, J = 11.6 Hz, 2H), 3.21 (t, J = 7.0 Hz, 2H), 3.11 (s, 2H), 2.992.84 (m, 3H), 2.74 (d, J = 12.0 Hz, 1H), 2.61 (d, J = 20.3 Hz, 1H), 2.562.52 (m, 1H), 2.05 (d, J = 12.4 Hz, 3H), 1.90 (dd, J = 24.6, 10.6 Hz, 4H), 1.73 (d, J = 6.8 Hz, 2H), 1.19 (s, 9H)

Data from cohorts of children with ASD indicate that up to 80% exhibit biomarkers of mitochondrial dysfunction , particularly within Complex I and IV of the electron transport chain (ETC) [3, 4]