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Dysbiosis and increased intestinal permeability (leaky gut) may amplify neuroinflammatory state of the brain, further justifying the need for research into interventions combining metabolic and microbiota-based therapies

We note that the trafficking of ROS-stimulated mitochondria from the periphery to opposite sides of the cell did occasionally occur during our experimental timescales, suggesting that rapid trafficking of ROS-damaged mitochondria across the cell is a potential avenue for mitochondrial ROS signaling open for further study

Kynurenine involvement may account for the protection afforded to animals with cerebral malaria and trypanosomiasis when they are treated with an inhibitor of kynurenine-3-monoxygenase (KMO)

This probe has unparalleled advantages, such as less light drift and background signal and higher spatiotemporal resolution than single fluorescence-based probes