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While all of the drugs in the class have been shown to produce some metabolic changes, each drug has its own specific risk profile

*Correspondence: Tao Yang, [email protected] A

33:73-76 Singhal RP, DeSilva SSM

In a phase 1 trial (NCT03792672) in healthy volunteers, TAK-653 was well tolerated, with no serious adverse events [118]

Gamma-glutamyl transpeptidase from Pseudomonas syringae (PsGGT) has been reported to utilize asparagine in addition to glutamine as a donor substrate and catalyze the transfer of -aspartyl and -glutamyl moiety to hydroxylamine, respectively (Prihanto et al., 2015a)