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Mass spectrometry infrastructure in this work was partly supported by AMED-CREST (to Y.K.), and Platform for Drug Discovery, Informatics, and Structural Life Science from the ministry of Education, Culture, Sports, Science and Technology, Japan (T.K.)

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However, upon concluding the experimental study, it became evident that the average live weights of rats in the ACR and MEL10+ACR groups were notably lower than those in the other groups ( p 0.05), suggesting a protective effect of MEL at higher doses

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