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Description

These compounds can be retained, separated, and analyzed using a reverse-phase Primesep 100, 4.6 x 150 mm, 5 m, 100 A, dual ended column

The trial did not meet its efficacy endpoint, but tolerability was not the reason the program was discontinued

In TGR, and more generally in TrxRs, electron transfer from NADPH to the enzyme is fast and practically irreversible and so an actual ES complex (NADPH-TGR) is not significantly populated during the catalytic cycle 17