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hepcidin also downregulates its synthesis through a negative feedback loop depending on circulating iron concentration to prevent iron overload in the body (Yao and Li, 2023)

FIGURE 1 3 Environmental and lifestyle drivers of accelerated ovarian aging A growing body of evidence supports the notion that menopause timing is not solely genetically determined but is significantly influenced by lifestyle and environmental exposures

The complete set of differentially expressed proteins and their functions is summarized in Table 3A

doi: 10.1016/j.cmet.2017.01.005 162 LeetePOramRAMcDonaldTJShieldsBMZillerCT.S

Method Enzymology Vol