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Specifically, O 2 is produced by NOS, uncoupled eNOS, xanthine oxidase, cyclo-oxygenase (COX), and the enzyme of the mitochondrial respiratory chain (79)

Linearity was verified using the coefficient of determination ( R 2 ) based on standard additions SA1, SA2, and the unspiked sample for low, medium, and high concentration levels (Tables S1 and S5)

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Nanomaterials as Microglia Modulators in the Treatment of Central Nervous System Disorders