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Nishijima C, Chiba T, Sato Y, Umegaki K

The incidence of congenital hypothyroidism is relatively high (1:4,000) and the hypothyroid fetus would not derive any benefit from the small amounts of hormone crossing the placental barrier

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Whats more, experiments employing BI1 overexpression and knockout demonstrated significant regulation of the TGF-1/PI3K/AKT/mTOR pathway, further confirming that lisinoprils modulation of TGF- pathway depended on BI1 (Fig