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Sandulache VC, Ow TJ, Daram SP, Hamilton J, Skinner H, Bell D, Rosenthal DI , Beadle BM, Ang KK, Kies MS, Johnson FM, El-Naggar AK, Myers JN

The accumulation of multiple ACs (especially LCACs) in children with abnormal liver function caused by VPA indicates dysfunction of mitochondrial fatty acid -oxidation

The mechanism might involve direct antiemetic effects of B12, or it might reflect improved overall metabolic function when vitamin status is maintained