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Hypokalaemia may also lead to increased ammoniagenesis, which results in more rapid progression of CKD

in vitro

A number of studies report that flavokavains A and B are the most cytotoxic compounds identified in kava [152], and one study particularly demonstrated its toxicity towards cells of liver origin and showed that they increased the cellular level of AST, indicative of potential liver toxicity [188]

Studies have shown that local COX-2 overexpression increases the number of CD90 + mouse skeletal stem cells (mSSCs) at the fracture site and targets CD90 + mSSCs to enhance canonical Wnt signal transduction, which results in the promotion of intramembranous osteogenesis and inhibition of intrachondral osteogenesis