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Glossary AD Alzheimers Disease AKT Protein kinase B APP Amyloid precursor protein ATP Adenosine triphosphate BDNF Brain-derived neurotrophic factor CREB cAMP response element-binding protein CTX Cortex C/EBP CCAAT-enhancer-binding proteins EA Erinacine A EB Erinacine B EC Erinacine C EF Erinacine F EL Erinacine L ERK1/2 Extracellular signal-regulated kinase 1/2 ES Erinacine S EZ1 Erinacine Z1 EZ2 Erinacine Z2 GLT-1 Glutamate transporter 1 GSK-3 Glycogen synthase kinase-3 beta HE Hericium erinaceus HEM Hericium erinaceus mycelia HEME Hericium erinaceus mycelia extracts Hip Hippocampus H 2 O 2 Hydrogen peroxide HO-1 Heme oxygenase-1 ICR Institute of Cancer Research IFN- Interferon-gamma IL-6 Interleukin-6 iNOS Inducible nitric oxide synthase JNK c-Jun N-terminal kinase LIMK2 LIM domain kinase 2 LPS Lipopolysaccharide MAPK Mitogen-activated protein kinase MPP+ 1-Methyl-4-phenylpyridinium MPTP 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine NF-B Nuclear factor kappa-light-chain-enhancer of activated B cells NGF Nerve growth factor Nrf2 Nuclear factor erythroid 2-related factor 2 NT-3 Neurotrophin-3 OPC Oligodendrocytes progenitor cell PAK1 p21-activated kinase 1 PCR Polymerase chain reaction PI3K Phosphoinositide 3-kinase pCREB Phosphorylated CREB PRISMA Preferred Reporting Items for Systematic reviews and Meta-Analyses PS1 Presenilin 1 SAMP8 Senescence Accelerated Mouse-Prone 8 SCA3 Spinocerebellar ataxia type 3 SD Sprague Dawley SOD1 Superoxide dismutase 1 TBI Traumatic brain injury tBT Tert-butyl hydroperoxide tHI Transient hypoxia-ischemia TNF - Tumor necrosis factor-alpha Trk Tyrosine receptor kinase TrkA Tyrosine receptor kinase A TrkB Tyrosine receptor kinase B Trx Thioredoxin TrxR Thioredoxin reductase References 1 AggarwalN

283 In HCC, downregulation of the TGF- signaling pathway may imply loss of cancer suppressive activity, while upregulation leads to fibrosis and inflammation

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And in Japan, DKT has been integrated into the modern medical system as a prescription drug and is widely used for gastrointestinal diseases such as postoperative intestinal obstruction [324]