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Arterioscler Thromb Vasc Biol (2000) 20:20949

According to Doll et al. s research, overexpression of apoptosis-inducing factor Mitochondrial Associated 2(AIFM2, also known as FSP1) can reverse ferroptosis induced by GPX4 inhibition, which indicates that FSP1 has nothing to do with the mechanism of GPX4 (42)

170 ZhangW.TangR.BaG.LiM.LinH

This form is standard across the copper-peptide research field, since lyophilization preserves the peptides structural stability during storage and transport in a way that liquid formulations generally cannot match

Based on current advancements in oxidative stress research in breast cancer, we propose several innovative therapeutic approaches targeting the ROSPCD network for future development: (1) Oxidative stress-directed small-molecule drugs: Natural compounds such as curcumin can induce apoptosis by triggering mitochondrial ROS bursts and DNA damage while enhancing ferroptosis sensitivity through GPX4 inhibition