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Figure 3 4.3.1 Cell-derived exosomes In recent years, interest in therapeutic usage of cell derivatives such as exosomes over cell therapies has been increasing (149, 150)

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297 Another known heterochromatin regulator, retinoblastoma protein (Rb), antagonizes the activation of LINE1 in senescent cells and decreases the percentage of Rb on the LINE1 promoter in senescent human cells and senescent mouse tissues