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Kaarteenaho-Wiik R, Kinnula VL

Conditional deletion of the mitochondrial transcription factor A (Tfam) in CD4 + T cells led to an imbalance in the NAD + /NADH ratio of mitochondria, which induced metabolic reprogramming toward glycolysis and thereby contributed to their pro-inflammatory phenotype, consequently exacerbating the in vivo immune response

doi: 10.1111/j.1460-9568.2006.04974.x